PUBLICATIONS & PREPRINTS

2025

• vom Stein AF, Nguyen PH, ten Hacken E (2025) A question of TiME: how microenvironmental interactions shape response to immunotherapy in CLL and Richter’s Transformation. Front Immunol 16:1592574. doi:10.3389/fimmu.2025.1592574
• Kohlhas V*^§, Jestrabek J^§, Rebollido-Rios R, Truong TT, Zölzer R, Schreurs LD, von Lom A, vom Stein AF, Hallek M, Nguyen PH*: Comparative analysis of macrophage feeder systems reveals distinct behaviors and key transcriptional shifts in chronic lymphocytic leukemia cells via coculture. bioRxiv 2025.02.13.638101
• Kohlhas V, Reinart N, Rosen N, Reinartz S, Nguyen PH*, Hallek M*: Systemic MIF facilitates chronic lymphocytic leukemia development independent of its cellular source. bioRxiv 2025.02.22.639632

2024

• Schreurs LD, vom Stein AF, Junger ST, Timmer M, Noh KW, Buettner R, Kashkar H, Neuschmelting V, Goldbrunner R*, Nguyen PH* (2025) The Immune Landscape in Brain Metastasis. Neuro Oncol. doi:10.1093/neuonc/noae219
• Jestrabek H, Kohlhas V, Hallek M, Nguyen PH (2024) Impact of leukemia-associated macrophages on the progression and therapy response of chronic lymphocytic leukemia. Leuk Res 143:107531. doi:10.1016/j.leukres.2024.10753
• Iqbal S, Schneider TK, Truong TT, Ulrich-Muller R, Nguyen PH, Ilyas S, Mathur S (2024) Carriers for hydrophobic drug molecules: lipid-coated hollow mesoporous silica particles, and the influence of shape and size on encapsulation efficiency. Nanoscale. doi:10.1039/d4nr01420k

2023

• vom Stein AF, Hallek M, Nguyen PH (2023) Role of the tumor microenvironment in CLL pathogenesis. Semin Hematol. doi:10.1053/j.seminhematol.2023.12.004
• Braun T, Pruene A, Darguzyte M, Vom Stein AF, Nguyen PH, Wagner DL, Kath J, Roig-Merino A, Heuser M, Riehm LL, Schneider A, Awerkiew S, Talbot SR, Bleich A, Figueiredo C, Bornhauser M, Stripecke R (2023) Non-viral TRAC-knocked-in CD19(KI)CAR-T and gp350(KI)CAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency. Front Immunol 14:1086433. doi:10.3389/fimmu.2023.1086433
• vom Stein AF, Rebollido-Rios R, Lukas A, Koch M, von Lom A, Reinartz S, Bachurski D, Rose F, Bozek K, Abdallah AT, Kohlhas V, Saggau J, Zolzer R, Zhao Y, Bruns C, Brockelmann PJ, Lohneis P, Buttner R, Haupl B, Oellerich T, Nguyen PH*, Hallek M* (2023) LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1. Nat Commun 14 (1):1330. doi:10.1038/s41467-023-36824-2
• Flumann R, Hansen J, Pelzer BW, Nieper P, Lohmann T, Kisis I, Riet T, Kohlhas V, Nguyen PH, Peifer M, Abedpour N, Bosco G, Thomas RK, Kochanek M, Knufer J, Jonigkeit L, Beleggia F, Holzem A, Buttner R, Lohneis P, Meinel J, Ortmann M, Persigehl T, Hallek M, Calado DP, Chmielewski M, Klein S, Gothert JR, Chapuy B, Zevnik B, Wunderlich FT, von Tresckow B, Jachimowicz RD, Melnick AM, Reinhardt HC, Knittel G (2023) Distinct Genetically Determined Origins of Myd88/BCL2-Driven Aggressive Lymphoma Rationalize Targeted Therapeutic Intervention Strategies. Blood Cancer Discov 4 (1):78-97. doi:10.1158/2643-3230.BCD-22-0007

2022

• de Oliveira TD, Vom Stein A, Rebollido-Rios R, Lobastova L, Lettau M, Janssen O, Wagle P, Nguyen PH, Hallek M, Hansen HP (2022) Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through Lyn-driven extracellular vesicles. Front Med (Lausanne) 9:1059028. doi:10.3389/fmed.2022.1059028
• Theobald SJ, Simonis A, Mudler JM, Gobel U, Acton R, Kohlhas V, Albert MC, Hellmann AM, Malin JJ, Winter S, Hallek M, Walczak H, Nguyen PH, Koch M, Rybniker J (2022) Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med 14 (8):e15888. doi:10.15252/emmm.202215888
• Knauer N, Arkhipova V, Li G, Hewera M, Pashkina E, Nguyen PH, Meschaninova M, Kozlov V, Zhang W, Croner RS, Caminade AM, Majoral JP, Apartsin EK, Kahlert UD (2022) In Vitro Validation of the Therapeutic Potential of Dendrimer-Based Nanoformulations against Tumor Stem Cells. Int J Mol Sci 23 (10). doi:10.3390/ijms23105691
• Rusyn L, Reinartz S, Nikiforov A, Mikhael N, Vom Stein A, Kohlhas V, Bloehdorn J, Stilgenbauer S, Lohneis P, Buettner R, Robrecht S, Fischer K, Pallasch C, Hallek M, Nguyen PH*, Seeger-Nukpezah T* (2022) The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia. Leukemia 36 (7):1794-1805. doi:10.1038/s41375-022-01586-1

2019 – 2021

• Lobastova L, Lettau M, Babatz F, de Oliveira TD, Nguyen PH, Pauletti BA, Schauss AC, Durkop H, Janssen O, Paes Leme AF, Hallek M, Hansen HP (2021) CD30-Positive Extracellular Vesicles Enable the Targeting of CD30-Negative DLBCL Cells by the CD30 Antibody-Drug Conjugate Brentuximab Vedotin. Front Cell Dev Biol 9:698503. doi:10.3389/fcell.2021.698503
• Kohlhas V, Hallek M*, Nguyen PH* (2020) Constitutive activation of Lyn kinase enhances BCR responsiveness, but not the development of CLL in Emicro-TCL1 mice. Blood Adv 4 (24):6106-6116. doi:10.1182/bloodadvances.2020002584
• Koch M, Reinartz S, Saggau J, Knittel G, Rosen N, Fedorchenko O, Thelen L, Barthel R, Reinart N, Seeger-Nukpezah T, Reinhardt HC, Hallek M, Nguyen PH (2020) Meta-Analysis Reveals Significant Sex Differences in Chronic Lymphocytic Leukemia Progression in the Emicro-TCL1 Transgenic Mouse Model. Cancers (Basel) 12 (7). doi:10.3390/cancers12071980
• Barthel R, Fedorchenko O, Velmans T, Rosen N, Nguyen PH, Reinart N, Florin A, Herling M, Hallek M, Fingerle-Rowson G (2020) CD74 is dispensable for development of chronic lymphocytic leukemia in Eµ-TCL1 transgenic mice. Leuk Lymphoma 61 (12):2799-2810. doi:10.1080/10428194.2020.1791851
• Nguyen PH*, Niesen E*, Hallek M (2019) New roles for B cell receptor associated kinases: when the B cell is not the target. Leukemia 33 (3):576-587. doi:10.1038/s41375-018-0366-8
• Bachurski D, Schuldner M, Nguyen PH, Malz A, Reiners KS, Grenzi PC, Babatz F, Schauss AC, Hansen HP, Hallek M, Pogge von Strandmann E (2019) Extracellular vesicle measurements with nanoparticle tracking analysis – An accuracy and repeatability comparison between NanoSight NS300 and ZetaView. J Extracell Vesicles 8 (1):1596016. doi:10.1080/20013078.2019.1596016

2016 – 2018

• Knittel G, Rehkamper T, Korovkina D, Liedgens P, Fritz C, Torgovnick A, Al-Baldawi Y, Al-Maarri M, Cun Y, Fedorchenko O, Riabinska A, Beleggia F, Nguyen PH, Wunderlich FT, Ortmann M, Montesinos-Rongen M, Tausch E, Stilgenbauer S, L PF, Herling M, Herling C, Bahlo J, Hallek M, Peifer M, Buettner R, Persigehl T, Reinhardt HC (2017) Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia. Nat Commun 8 (1):153. doi:10.1038/s41467-017-00210-6
• Nguyen PH, Fedorchenko O, Rosen N, Koch M, Barthel R, Winarski T, Florin A, Wunderlich FT, Reinart N, Hallek M (2016) LYN Kinase in the Tumor Microenvironment Is Essential for the Progression of Chronic Lymphocytic Leukemia. Cancer Cell 30 (4):610-622. doi:10.1016/j.ccell.2016.09.007

2013

• Reinart N, Nguyen PH, Boucas J, Rosen N, Kvasnicka HM, Heukamp L, Rudolph C, Ristovska V, Velmans T, Mueller C, Reiners KS, von Strandmann EP, Krause G, Montesinos-Rongen M, Schlegelberger B, Herling M, Hallek M, Fingerle-Rowson G (2013) Delayed development of chronic lymphocytic leukemia in the absence of macrophage migration inhibitory factor. Blood 121 (5):812-821. doi:10.1182/blood-2012-05-431452
• Schmitt F*, Nguyen PH*, Gupta N, Mayer D (2013) Eph receptor B4 is a regulator of estrogen receptor alpha in breast cancer cells. J Recept Sig Transd 33 (4):244-248. doi:10.3109/10799893.2013.795971

Book Chapter

• Do TTH, Le PQH, Nguyen HNT, Pham, NNL, Nguyen DTN, Nguyen PH, Thao NP (2025) Network Pharmacology of Ginseng: Modern Insights of a Traditional Medicine. In Chen JT (Ed), Medicinal plant molecular biology and biotechnology: From metabolomics, functional genomics towards precision breeding. CRC Press/Taylor & Francis Group, LLC